Phentolamine Two controlled studies have investigated the effect of the alpha-1 and alpha-2 adrenergic receptor antagonist phentolamine on the basis of the hypothesis that, as in men, the smooth muscle surrounding the vaginal arterial vascular bed is mainly alpha adrenergically innervatedn the first study, an oral application was used that showed a certain effect on subjective and genital sexual arousal (VPA) in postmenopausal women with sexual arousal issues second placebo-controlled analysis studied both oral and vaginal applications in estrogenized and nonestrogenized postmenopausal womenenital response was higher with the highest dose of vaginally applied phentolamine than with placebo, in estrogenized postmenopausal women onlyubjective sexual arousal was higher with the highest doses of both applications of phentolamine than with placebo, again in the estrogenized women onlyopamine Agonists Dopaminergic drugs could be interesting given that unlike the previously di ... [Read More - Why Do Men Premature Ejaculate]

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